The crossover of sorts based on the American animated television series The Powerpuff Girls, The Powerpuff Girls Doujinshi (Comic) and The Powerpuff Girls Z (anime), though finding Blossom, Bubbles, and Buttercup slightly older and now going to school in a fictional neighboring city of Townsville known as Megaville. Evil forces soon set their sights on the girls, which lead to conflicts as the comic progresses. So far besides the character of the Powerpuff Girls, this television series and anime also features characters from: Dexter's Laboratory and The Amazing World of Gumball though a large amount of them being merely references.
- Professor Utonium
- Nicole Watterson
- Dee Dee
- Richard Watterson
- Anais Watterson
- Main article: List of The Powerpuff Girls Crossover episodes
A Second Season titled The Powerpuff Girls Crossover 2 will be released on 2013.